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Gastric Varies RCT
Image Credit: Explode / Shutterstock.com
Primary prophylaxis of gastric varices is an important area of research, as gastric varices are a common complication of cirrhosis of the liver. Cirrhosis is a condition in which the liver becomes scarred and loses its ability to function properly, and it is a leading cause of morbidity and mortality worldwide. Gastric varices occur in up to 30% of patients with cirrhosis, and they can rupture, leading to life-threatening bleeding. The clinical, epidemiological, and public health context of primary prophylaxis of gastric varices is therefore the need to prevent the development of this complication in patients at risk for cirrhosis and to reduce the associated morbidity and mortality. The clinical trials on primary prophylaxis of gastric varices are therefore focused on evaluating the safety and efficacy of various interventions, such as beta-blockers and endoscopic techniques, in reducing the risk of gastric varices in patients with cirrhosis. The goal of this trial is to find the most effective and safe strategies for primary prophylaxis of gastric varices, in order to improve the outcomes for patients with cirrhosis.
Medium Size Polyp Resection
Polyps are growths that develop on the lining of the digestive tract and can vary in size. Polyps that are sized between 10 and 20 mm are considered to be medium-sized polyps. In general, endoscopists will recommend removal of medium-sized polyps through a procedure called endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD). These procedures involve using specialized endoscopic instruments to remove the polyp from the digestive tract.
After removing the polyp, the endoscopist will typically send it to a laboratory for examination under a microscope to determine if it is benign (non-cancerous) or malignant (cancerous). If the polyp is found to be benign, no further treatment is usually necessary. However, if the polyp is found to be malignant, the endoscopist may recommend additional treatment, such as chemotherapy or surgery, to remove any remaining cancerous tissue.
In some cases, endoscopists may recommend surveillance of medium-sized polyps to monitor for any changes in size or appearance over time. This can help to ensure that any potential abnormalities are caught and treated early, before they have a chance to progress and cause serious health problems.
Pancreatic Necrosis Study
This study aims to analyze the long-term patient-oriented outcomes of different drainage modalities in patients with pancreatic necrosis by analyzing population-level data. The study will also identify current practices in the management of these patients and trends over the years. The data will be collected from routine healthcare records, and patient information will be de-identified to maintain confidentiality.
Complex Polyp Delphi
The primary objective of this study will be to establish minimum expected standards for the referral of large colorectal polyps for potential endoscopic resection. These standards will include consensus agreements on patient demographic information, polyp descriptions, and the inclusion and quality of endoscopic images/videos in a referral request for endoscopic resection to allow adequate planning and assessment of the polyp for the receiving provider.
Comparing the Effectiveness and Safety of EMT vs ESD for BE: Prospective, Multicentre Trial
The increasing incidence of esophageal adenocarcinoma in patients with Barrett's esophagus highlights the need for effective management strategies for early Barrett's neoplasia. While EMR and ESD are two commonly used techniques for resecting early neoplastic lesions, there is no consensus on which technique is superior in terms of clinical outcomes and safety. Thus, a prospective, multicentre study is needed to compare the effectiveness and safety of EMR and ESD for the treatment of early Barrett's neoplasia.